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yngG [2017-8-11 16:0:3]

3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) lyase

locus

BSU18230

5.75

32.49 kDa

protein length

299 aa Sequence Blast

gene length

897 bp Sequence Blast

function

mother cell metabolism, leucine utilization

product

3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) lyase

essential

4.1.3.4

synonyms

Outlinks

KEGG BsubCyc SubtiList UniProt Expression Browser

Genomic Context

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categories

[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.9|Utilization of branched-chain amino acids]

[category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]

Gene

Coordinates

1,952,031 → 1,952,930

The protein

Catalyzed reaction/ biological activity

(S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate [Pubmed|19935659]

Protein family

HMG-CoA lyase family (according to Swiss-Prot)

Structure

[PDB|1YDO]

Expression and Regulation

Operons

genes

description

[Pubmed|12662922]

sigma factors

regulation

expressed during sporulation in the mother cell ([protein|search|SigE]) [Pubmed|15699190,12662922]

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References

15699190,12662922,16330546,18943917,19935659